I own a 94 Ford Explorer with 5 spd manual and 4.0 V6 with 180K on the clock and it runs as good as the day I bought it.
Major maintenance includes: Water Pump, I beam locator Bushings (2X, this is a design problem), Transmission.
Routine Maintenance: Battery (4X), Tires (3X), Brakes (need to replace front rotors next brake job).

2004 Nissan Quest - 40K on the ticker, no major maintenance.

2004 Corvette - Change the oil after every track day![8D]

And now a Mazda 5 on a 2 year lease.

All cars are in great shape. It's making sure you keep up with the routine maintenance, and keeping them clean that is important.